SEROTONIN RECEPTOR SUBTYPES, THEIR CHARACTERISTICS, AND LIGANDS

5-HT1A

• antianxiety
• antidepressant
• antiaggressive
• anticraving
• anticataleptic
• antiemetic
• neuroprotective
• impulsivity
• alcoholism
• phases of sleep
• obsessive-compulsive disorders
• sexual behavior
• appetite control
• thermoregulation

5-HT1B

• sleep regulation
• sensorimotor inhibition
• locomotor activity
• aggressive behavior

5-HT1D

• anxiety
• depression
• migraines
• role in Huntington's disease

5-HT2A

• appetite control
• thermoregulation
• sleep
• 5-HT2 component of binding may be related to the decrease in extrapyramidal side effects associated atypical antipsychotics

5-HT2C

• eating disorders
• epilepsy

5-HT3

• treatment of chemotherapy-induced or radiation-induced nausea and vomiting, whereas they are ineffective against motion sickness and apomorphine-induced emesis
• migraine
• may enhance memory
• anxiety
• depression
• dementia
• may suppress the behavioral consequences of withdrawing chronic treatment with drugs of abuse, including alcohol, nicotine, cocaine, and amphetamine

5-HT4

• role in cognitive function
• anxiety
• reward system and may influence self-administration behavior

5-HT7

• mood
• learning
• neuroendocrine and vegetative behaviors